Neuravena® is a green oat extract sourced from a unique strain of Avena sativa L. known for its positive effects on cognitive markers. Because Frutarom works with contract farmers to cultivate this proprietary oat variety, we exercise full control over quality, safety and identify from field to finished product.
Why oat? Because oat enjoys a long history of contributing to physical and psychological health. Monographs convey oat’s record of mental and cognitive support, from reducing anxiety to helping manage stress. And in a first among oat extracts, Neuravena® substantiated these benefits via rigorous clinical studies.
Neuravena® is clinically proven safe and effective. On the safety side, our patented Hyperpure® technology guarantees the absence of contaminants. As for effectiveness, five clinical studies confirm Neuravena®’s benefits to cognitive function.
As an ingredient, Neuravena® suits a range of applications, from traditional supplement capsules and tablets to functional food and beverage options.
Enhance blood circulation
(Wong et al.)
Stimulate the left frontotemporal area
(Dimpfel et al.)
Support dopamine level
Neuravena® a cognitive support for:
Concentration and alertness
(Berry et al.)
(Kennedy et al.)
(Dimpfel et al., Kennedy et al.)
|Neuravena® improved speed of performance, working memory, episodic memory and executive function
Kennedy et al. Acute effects of a wild green oats (Avena sativa) extract on cognitive function in middle-aged adults: a double-blind, placebo controlled, randomised, within-subjects trial. Nutritional, Neuroscience, 2015.
Neuravena® influenced positively EEG spectral frequencies
|Neuravena® significantly improved responses to the Stroop Color-Word test, broadly used in clinical assessment of attention.
Berry et al. Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test, J Altern Complement Med 2011, 17, 635-637.
|Neuravena® improved brachial flow-mediated dilatation and cerebrovascular responsiveness.
Wong et al. Chronic consumption of a wild green oat extract (Neuravena®) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults, J Hypertens 2013, 31, 192-200.
|Neuravena® mediated positive effects on memory function and helped reduce the number of cigarettes smoked per day.
Fujii et al. Pilot Study of the Standardized Oats Herb Extract for Smoking Reduction, Pharmacometrics 2008, 75, 47-53.
Mode of Action
Research demonstrates that Neuravena® acts via two mechanisms that impact both cognition and mental health:
- Inhibition of the enzyme monoamine oxidase B (MAO-B)
- Inhibition of the enzyme phosphodiesterase 4 (PDE4)
Both enzymes act on the central nervous system and are believed to play a role in mental health and cognitive function, perhaps via their modulatory effects on anxiety, memory and depression. Besides MAO-B and PDE4 inhibition, other mechanisms may also be involved in Neuravena®’s ability to improve mental alertness. As the science on Neuravena® unfolds, we continue to uncover exciting possibilities.
Phosphodiesterase 4 inhibition by Neuravena®
About Frutarom Health
Years of experience have made Frutarom Health, a leading global manufacturer of high-quality health ingredients backed by the science, and supported with documentation and the regulatory compliance our customers demand.
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